Difference between revisions of "YMR067C"
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| − | '''Description of YMR067C:''' UBX | + | '''Description of YMR067C:''' UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome<ref name='S000135342'>Alberts SM, et al. (2009) Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. J Biol Chem 284(24):16082-9 {{SGDpaper|S000135342}} PMID 19359248</ref><ref name='S000076733'>Schuberth C, et al. (2004) Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep 5(8):818-24 |
{{SGDpaper|S000076733}} PMID 15258615</ref> | {{SGDpaper|S000076733}} PMID 15258615</ref> | ||
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Revision as of 14:05, 30 November 2011
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| Systematic name | YMR067C |
| Gene name | UBX4 |
| Aliases | CUI1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:405573..404323 |
| Primary SGDID | S000004671 |
Description of YMR067C: UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome[1][2]
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References
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- ↑ Alberts SM, et al. (2009) Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. J Biol Chem 284(24):16082-9 SGD PMID 19359248
- ↑ Schuberth C, et al. (2004) Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep 5(8):818-24 SGD PMID 15258615
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