Difference between revisions of "YMR026C"
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| − | '''Description of YMR026C:''' C3HC4-type RING-finger | + | '''Description of YMR026C:''' C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder<ref name='S000060328'>Albertini M, et al. (2001) Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import. Eur J Cell Biol 80(4):257-70 {{SGDpaper|S000060328}} PMID 11370741</ref><ref name='S000058069'>Chang CC, et al. (1997) Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders. Nat Genet 15(4):385-8 {{SGDpaper|S000058069}} PMID 9090384</ref><ref name='S000078434'>Hazra PP, et al. (2002) Peroxisome remnants in pex3delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Traffic 3(8):560-74 {{SGDpaper|S000078434}} PMID 12121419</ref><ref name='S000134908'>Platta HW, et al. (2009) Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import. Mol Cell Biol 29(20):5505-16 |
| − | {{SGDpaper| | + | {{SGDpaper|S000134908}} PMID 19687296</ref> |
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Revision as of 14:05, 21 July 2010
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| Systematic name | YMR026C |
| Gene name | PEX12 |
| Aliases | PAS11 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:325434..324235 |
| Primary SGDID | S000004628 |
Description of YMR026C: C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder[1][2][3][4]
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References
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- ↑ Albertini M, et al. (2001) Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import. Eur J Cell Biol 80(4):257-70 SGD PMID 11370741
- ↑ Chang CC, et al. (1997) Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders. Nat Genet 15(4):385-8 SGD PMID 9090384
- ↑ Hazra PP, et al. (2002) Peroxisome remnants in pex3delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Traffic 3(8):560-74 SGD PMID 12121419
- ↑ Platta HW, et al. (2009) Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import. Mol Cell Biol 29(20):5505-16 SGD PMID 19687296
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