Difference between revisions of "YLR060W"
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| − | '''Description of YLR060W:''' Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; | + | '''Description of YLR060W:''' Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control<ref name='S000086730'>Roy H, et al. (2005) Loss of editing activity during the evolution of mitochondrial phenylalanyl-tRNA synthetase. J Biol Chem 280(46):38186-92 {{SGDpaper|S000086730}} PMID 16162501</ref><ref name='S000077172'>Aphasizhev R, et al. (1996) Conservation in evolution for a small monomeric phenylalanyl-tRNA synthetase of the tRNA(Phe) recognition nucleotides and initial aminoacylation site. Biochemistry 35(1):117-23 {{SGDpaper|S000077172}} PMID 8555164</ref><ref name='S000052199'>Sanni A, et al. (1988) Structure and expression of the genes encoding the alpha and beta subunits of yeast phenylalanyl-tRNA synthetase. J Biol Chem 263(30):15407-15 |
{{SGDpaper|S000052199}} PMID 3049607</ref> | {{SGDpaper|S000052199}} PMID 3049607</ref> | ||
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Revision as of 07:21, 26 February 2009
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| Systematic name | YLR060W |
| Gene name | FRS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:260980..262767 |
| Primary SGDID | S000004050 |
Description of YLR060W: Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control[1][2][3]
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References
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- ↑ Roy H, et al. (2005) Loss of editing activity during the evolution of mitochondrial phenylalanyl-tRNA synthetase. J Biol Chem 280(46):38186-92 SGD PMID 16162501
- ↑ Aphasizhev R, et al. (1996) Conservation in evolution for a small monomeric phenylalanyl-tRNA synthetase of the tRNA(Phe) recognition nucleotides and initial aminoacylation site. Biochemistry 35(1):117-23 SGD PMID 8555164
- ↑ Sanni A, et al. (1988) Structure and expression of the genes encoding the alpha and beta subunits of yeast phenylalanyl-tRNA synthetase. J Biol Chem 263(30):15407-15 SGD PMID 3049607
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