Difference between revisions of "YKL173W"

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'''Description of YKL173W:''' GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2<ref name='S000039943'>Dix I, et al. (1998) Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae. RNA 4(12):1675-86 {{SGDpaper|S000039943}} PMID 9848662</ref><ref name='S000048254'>Fabrizio P, et al. (1997) An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. EMBO J 16(13):4092-106 {{SGDpaper|S000048254}} PMID 9233818</ref><ref name='S000056376'>Stevens SW and Abelson J (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31 {{SGDpaper|S000056376}} PMID 10377396</ref><ref name='S000081766'>Brenner TJ and Guthrie C (2005) Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics 170(3):1063-80
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'''Description of YKL173W:''' GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2<ref name='S000081766'>Brenner TJ and Guthrie C (2005) Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics 170(3):1063-80 {{SGDpaper|S000081766}} PMID 15911574</ref><ref name='S000056376'>Stevens SW and Abelson J (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31 {{SGDpaper|S000056376}} PMID 10377396</ref><ref name='S000048254'>Fabrizio P, et al. (1997) An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. EMBO J 16(13):4092-106 {{SGDpaper|S000048254}} PMID 9233818</ref><ref name='S000039943'>Dix I, et al. (1998) Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae. RNA 4(12):1675-86
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Revision as of 14:05, 16 January 2009

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Systematic name YKL173W
Gene name SNU114
Aliases GIN10
Feature type ORF, Verified
Coordinates Chr XI:122522..125548
Primary SGDID S000001656


Description of YKL173W: GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2[1][2][3][4]




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References

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  1. Brenner TJ and Guthrie C (2005) Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics 170(3):1063-80 SGD PMID 15911574
  2. Stevens SW and Abelson J (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31 SGD PMID 10377396
  3. Fabrizio P, et al. (1997) An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. EMBO J 16(13):4092-106 SGD PMID 9233818
  4. Dix I, et al. (1998) Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae. RNA 4(12):1675-86 SGD PMID 9848662

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