YDR180W

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Systematic name YDR180W
Gene name SCC2
Aliases
Feature type ORF, Verified
Coordinates Chr IV:821295..825776
Primary SGDID S000002588


Description of YDR180W: Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin[1][2][3][4][5]




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References

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  1. Ciosk R, et al. (2000) Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins. Mol Cell 5(2):243-54 SGD PMID 10882066
  2. Furuya K, et al. (1998) Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase. Genes Dev 12(21):3408-18 SGD PMID 9808627
  3. Michaelis C, et al. (1997) Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 91(1):35-45 SGD PMID 9335333
  4. Strom L, et al. (2004) Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair. Mol Cell 16(6):1003-15 SGD PMID 15610742
  5. Unal E, et al. (2004) DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell 16(6):991-1002 SGD PMID 15610741

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