YNR047W

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Systematic name YNR047W
Gene name FPK1
Aliases
Feature type ORF, Verified
Coordinates Chr XIV:708523..711204
Primary SGDID S000005330


Description of YNR047W: Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane[1][2][3][4]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]





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References

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  1. Burchett SA, et al. (2001) Identification of novel pheromone-response regulators through systematic overexpression of 120 protein kinases in yeast. J Biol Chem 276(28):26472-8 SGD PMID 11337509
  2. Nakano K, et al. (2008) Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry. Mol Biol Cell 19(4):1783-97 SGD PMID 18199685
  3. Roelants FM, et al. (2010) A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A 107(1):34-9 SGD PMID 19966303
  4. 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  5. submitted by Jeff Ubersax on 2004-01-29

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