YNL299W

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Systematic name YNL299W
Gene name TRF5
Aliases
Feature type ORF, Verified
Coordinates Chr XIV:66517..68445
Primary SGDID S000005243


Description of YNL299W: Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p[1][2][3][4][5]




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References

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  1. Egecioglu DE, et al. (2006) Contributions of Trf4p- and Trf5p-dependent polyadenylation to the processing and degradative functions of the yeast nuclear exosome. RNA 12(1):26-32 SGD PMID 16373491
  2. Haracska L, et al. (2005) Trf4 and Trf5 proteins of Saccharomyces cerevisiae exhibit poly(A) RNA polymerase activity but no DNA polymerase activity. Mol Cell Biol 25(22):10183-9 SGD PMID 16260630
  3. Houseley J and Tollervey D (2006) Yeast Trf5p is a nuclear poly(A) polymerase. EMBO Rep 7(2):205-11 SGD PMID 16374505
  4. LaCava J, et al. (2005) RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. Cell 121(5):713-24 SGD PMID 15935758
  5. Vanacova S, et al. (2005) A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol 3(6):e189 SGD PMID 15828860

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