YMR001C

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Systematic name YMR001C
Gene name CDC5
Aliases MSD2, PKX2
Feature type ORF, Verified
Coordinates Chr XIII:271136..269019
Primary SGDID S000004603


Description of YMR001C: Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate[1][2][3][4]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]





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References

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  1. Alexandru G, et al. (2001) Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell 105(4):459-72 SGD PMID 11371343
  2. Hu F and Elledge SJ (2002) Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle 1(5):351-5 SGD PMID 12461298
  3. Iacovella MG, et al. (2010) Analysis of Polo-like kinase Cdc5 in the meiosis recombination checkpoint. Cell Cycle 9(6) SGD PMID 20237423
  4. 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  5. submitted by Jeff Ubersax on 2004-01-29

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