YMR037C

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Systematic name YMR037C
Gene name MSN2
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:346517..344403
Primary SGDID S000004640


Description of YMR037C: Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression[1][2]




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Interactions

Regulatory

Regulatory interaction with YBL064c
YBL064c is up regulated by Msn2p/Msn4p during glucose exhaustion (cells grown in respiratory carbon sources, such as glycerol / ethanol). Exogenously added cAMP represses the induction of YBL064c mRNA expression even in respiratory conditions. [3] [4]





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References

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  1. Gorner W, et al. (1998) Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev 12(4):586-97 SGD PMID 9472026
  2. Martinez-Pastor MT, et al. (1996) The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE). EMBO J 15(9):2227-35 SGD PMID 8641288
  3. Monteiro G, et al. (2002) Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Free Radic Biol Med 32(3):278-88 SGD PMID 11827753
  4. submitted by Gisele Monteiro on 2003-03-31

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