YHR079C

From SGD-Wiki
(Redirected from IRE1)
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YHR079C
Gene name IRE1
Aliases ERN1
Feature type ORF, Verified
Coordinates Chr VIII:261591..258244
Primary SGDID S000001121


Description of YHR079C: Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress[1][2][3]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!




<protect>

References

See Help:References on how to add references

  1. Okamura K, et al. (2000) Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast. Biochem Biophys Res Commun 279(2):445-50 SGD PMID 11118306
  2. Sidrauski C and Walter P (1997) The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90(6):1031-9 SGD PMID 9323131
  3. Welihinda AA and Kaufman RJ (1996) The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation. J Biol Chem 271(30):18181-7 SGD PMID 8663458

See Help:Categories on how to add the wiki page for this gene to a Category </protect>