YMR246W

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Systematic name YMR246W
Gene name FAA4
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:759807..761891
Primary SGDID S000004860


Description of YMR246W: Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism[1][2][3][4][5]




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References

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  1. Ashrafi K, et al. (1998) A role for Saccharomyces cerevisiae fatty acid activation protein 4 in regulating protein N-myristoylation during entry into stationary phase. J Biol Chem 273(40):25864-74 SGD PMID 9748261
  2. Athenstaedt K, et al. (1999) Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. J Bacteriol 181(20):6441-8 SGD PMID 10515935
  3. Johnson DR, et al. (1994) Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism. J Cell Biol 127(3):751-62 SGD PMID 7962057
  4. Nakahara K, et al. (2012) The sjogren-larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Mol Cell 46(4):461-71 SGD PMID 22633490
  5. Zou Z, et al. (2003) Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex. J Biol Chem 278(18):16414-22 SGD PMID 12601005

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