YNL172W

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Systematic name YNL172W
Gene name APC1
Aliases
Feature type ORF, Verified
Coordinates Chr XIV:310636..315882
Primary SGDID S000005116


Description of YNL172W: Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis[1][2][3][4]




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References

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  1. Buschhorn BA, et al. (2011) Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nat Struct Mol Biol 18(1):6-13 SGD PMID 21186364
  2. Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 SGD PMID 10465783
  3. Zachariae W, et al. (1996) Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274(5290):1201-4 SGD PMID 8895471
  4. Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 SGD PMID 9469814

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