YPR161C

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Systematic name YPR161C
Gene name SGV1
Aliases BUR1
Feature type ORF, Verified
Coordinates Chr XVI:866418..864445
Primary SGDID S000006365


Description of YPR161C: Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p, which is the largest subunit of RNA polymerase II; regulated by Cak1p[1][2][3][4][5]




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References

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  1. Keogh MC, et al. (2003) Bur1 kinase is required for efficient transcription elongation by RNA polymerase II. Mol Cell Biol 23(19):7005-18 SGD PMID 12972617
  2. Yao S and Prelich G (2002) Activation of the Bur1-Bur2 cyclin-dependent kinase complex by Cak1. Mol Cell Biol 22(19):6750-8 SGD PMID 12215532
  3. Murray S, et al. (2001) Phosphorylation of the RNA polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase. Mol Cell Biol 21(13):4089-96 SGD PMID 11390638
  4. Yao S, et al. (2000) BUR1 and BUR2 encode a divergent cyclin-dependent kinase-cyclin complex important for transcription in vivo. Mol Cell Biol 20(19):7080-7 SGD PMID 10982824
  5. Prelich G and Winston F (1993) Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo. Genetics 135(3):665-76 SGD PMID 8293972

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