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Systematic name YPR161C
Gene name SGV1
Aliases BUR1
Feature type ORF, Verified
Coordinates Chr XVI:866422..864449
Primary SGDID S000006365

Description of YPR161C: Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins[1][2][3][4][5][6][7]


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  1. Bartkowiak B, et al. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev 24(20):2303-16 SGD PMID 20952539
  2. Keogh MC, et al. (2003) Bur1 kinase is required for efficient transcription elongation by RNA polymerase II. Mol Cell Biol 23(19):7005-18 SGD PMID 12972617
  3. Liu Y, et al. (2009) Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Mol Cell Biol 29(17):4852-63 SGD PMID 19581288
  4. Murray S, et al. (2001) Phosphorylation of the RNA polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase. Mol Cell Biol 21(13):4089-96 SGD PMID 11390638
  5. Prelich G and Winston F (1993) Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo. Genetics 135(3):665-76 SGD PMID 8293972
  6. Yao S and Prelich G (2002) Activation of the Bur1-Bur2 cyclin-dependent kinase complex by Cak1. Mol Cell Biol 22(19):6750-8 SGD PMID 12215532
  7. Yao S, et al. (2000) BUR1 and BUR2 encode a divergent cyclin-dependent kinase-cyclin complex important for transcription in vivo. Mol Cell Biol 20(19):7080-7 SGD PMID 10982824

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