Difference between revisions of "YPL241C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YPL241C YPL241C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006162 YPL241C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''CIN2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''CIN2 ''
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|nowrap| Chr XVI:96258..95372
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000006162
 
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'''Description of {{PAGENAME}}:''' Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl<ref name='S000062059'>Tian G, et al. (1996) Pathway leading to correctly folded beta-tubulin. Cell 86(2):287-96 {{SGDpaper|S000062059}} PMID 8706133</ref><ref name='S000049262'>Stearns T, et al. (1990) Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124(2):251-62 {{SGDpaper|S000049262}} PMID 2407611</ref><ref name='S000042616'>Hoyt MA, et al. (1990) Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Mol Cell Biol 10(1):223-34
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'''Description of YPL241C:''' GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2<ref name='S000042616'>Hoyt MA, et al. (1990) Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Mol Cell Biol 10(1):223-34 {{SGDpaper|S000042616}} PMID 2403635</ref><ref name='S000049262'>Stearns T, et al. (1990) Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124(2):251-62 {{SGDpaper|S000049262}} PMID 2407611</ref><ref name='S000062059'>Tian G, et al. (1996) Pathway leading to correctly folded beta-tubulin. Cell 86(2):287-96 {{SGDpaper|S000062059}} PMID 8706133</ref><ref name='S000126008'>Veltel S, et al. (2008) The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol 15(4):373-80
  {{SGDpaper|S000042616}} PMID 2403635</ref>
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  {{SGDpaper|S000126008}} PMID 18376416</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YPL241C
Gene name CIN2
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:96258..95372
Primary SGDID S000006162


Description of YPL241C: GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2[1][2][3][4]




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References

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  1. Hoyt MA, et al. (1990) Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Mol Cell Biol 10(1):223-34 SGD PMID 2403635
  2. Stearns T, et al. (1990) Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124(2):251-62 SGD PMID 2407611
  3. Tian G, et al. (1996) Pathway leading to correctly folded beta-tubulin. Cell 86(2):287-96 SGD PMID 8706133
  4. Veltel S, et al. (2008) The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol 15(4):373-80 SGD PMID 18376416

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