Difference between revisions of "YPL127C"

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'''Description of YPL127C:''' Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation<ref name='S000073592'>Downs JA, et al. (2003) Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Mol Cell 11(6):1685-92 {{SGDpaper|S000073592}} PMID 12820979</ref><ref name='S000054174'>Escher D and Schaffner W (1997) Gene activation at a distance and telomeric silencing are not affected by yeast histone H1. Mol Gen Genet 256(4):456-61 {{SGDpaper|S000054174}} PMID 9393443</ref><ref name='S000065991'>Freidkin I and Katcoff DJ (2001) Specific distribution of the Saccharomyces cerevisiae linker histone homolog HHO1p in the chromatin. Nucleic Acids Res 29(19):4043-51 {{SGDpaper|S000065991}} PMID 11574687</ref><ref name='S000062790'>Hellauer K, et al. (2001) Decreased expression of specific genes in yeast cells lacking histone H1. J Biol Chem 276(17):13587-92 {{SGDpaper|S000062790}} PMID 11278859</ref><ref name='S000063502'>Landsman D (1996) Histone H1 in Saccharomyces cerevisiae: a double mystery solved? Trends Biochem Sci 21(8):287-8 {{SGDpaper|S000063502}} PMID 8772381</ref><ref name='S000043555'>Patterton HG, et al. (1998) The biochemical and phenotypic characterization of Hho1p, the putative linker histone H1 of Saccharomyces cerevisiae. J Biol Chem 273(13):7268-76 {{SGDpaper|S000043555}} PMID 9516420</ref><ref name='S000045120'>Puig S, et al. (1999) Stochastic nucleosome positioning in a yeast chromatin region is not dependent on histone H1. Curr Microbiol 39(3):168-72 {{SGDpaper|S000045120}} PMID 10441732</ref><ref name='S000041152'>Ushinsky SC, et al. (1997) Histone H1 in Saccharomyces cerevisiae. Yeast 13(2):151-61
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'''Description of YPL127C:''' Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination<ref name='S000150859'>Bryant JM, et al. (2012) The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae. Mol Cell Biol 32(14):2771-83 {{SGDpaper|S000150859}} PMID 22586276</ref><ref name='S000073592'>Downs JA, et al. (2003) Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Mol Cell 11(6):1685-92 {{SGDpaper|S000073592}} PMID 12820979</ref><ref name='S000054174'>Escher D and Schaffner W (1997) Gene activation at a distance and telomeric silencing are not affected by yeast histone H1. Mol Gen Genet 256(4):456-61 {{SGDpaper|S000054174}} PMID 9393443</ref><ref name='S000065991'>Freidkin I and Katcoff DJ (2001) Specific distribution of the Saccharomyces cerevisiae linker histone homolog HHO1p in the chromatin. Nucleic Acids Res 29(19):4043-51 {{SGDpaper|S000065991}} PMID 11574687</ref><ref name='S000062790'>Hellauer K, et al. (2001) Decreased expression of specific genes in yeast cells lacking histone H1. J Biol Chem 276(17):13587-92 {{SGDpaper|S000062790}} PMID 11278859</ref><ref name='S000063502'>Landsman D (1996) Histone H1 in Saccharomyces cerevisiae: a double mystery solved? Trends Biochem Sci 21(8):287-8 {{SGDpaper|S000063502}} PMID 8772381</ref><ref name='S000043555'>Patterton HG, et al. (1998) The biochemical and phenotypic characterization of Hho1p, the putative linker histone H1 of Saccharomyces cerevisiae. J Biol Chem 273(13):7268-76 {{SGDpaper|S000043555}} PMID 9516420</ref><ref name='S000045120'>Puig S, et al. (1999) Stochastic nucleosome positioning in a yeast chromatin region is not dependent on histone H1. Curr Microbiol 39(3):168-72 {{SGDpaper|S000045120}} PMID 10441732</ref><ref name='S000041152'>Ushinsky SC, et al. (1997) Histone H1 in Saccharomyces cerevisiae. Yeast 13(2):151-61
 
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Latest revision as of 14:05, 11 September 2012

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Systematic name YPL127C
Gene name HHO1
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:309604..308828
Primary SGDID S000006048


Description of YPL127C: Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination[1][2][3][4][5][6][7][8][9]




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Community Commentary

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Alleles, Strains, and Phenotypes

Complete Deletion

Strain Background: S288c
Genotype: BQS238: MATalfa, ura3-52, leu2-3,112, ade2-101, suc2-delta9, gal2, hho1delta0, pRB58
Phenotype(s): No Phenotype, Deletion of HHO1 has no effect on nucleosome positioning, Viable

Hho1p has no effect on nucleosome positioning in yeast. [8] [10]

DNA and RNA Details

Other DNA and RNA Details

Other Topic: Nucleosome positioning

We analyzed a chromatin region of the yeast Chromosome (Chr) IX, in which there are two closely packed open reading frames (ORFs), POT1 and YIL161w. This locus shows a regular ladder of 13 stochastically positioned nucleosomes, which is unaffected by the absence of the HHO1 gene. This suggests that histone H1 has no effect on nucleosome positioning in yeast. [8] [10]




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References

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  1. ↑ Bryant JM, et al. (2012) The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae. Mol Cell Biol 32(14):2771-83 SGD PMID 22586276
  2. ↑ Downs JA, et al. (2003) Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Mol Cell 11(6):1685-92 SGD PMID 12820979
  3. ↑ Escher D and Schaffner W (1997) Gene activation at a distance and telomeric silencing are not affected by yeast histone H1. Mol Gen Genet 256(4):456-61 SGD PMID 9393443
  4. ↑ Freidkin I and Katcoff DJ (2001) Specific distribution of the Saccharomyces cerevisiae linker histone homolog HHO1p in the chromatin. Nucleic Acids Res 29(19):4043-51 SGD PMID 11574687
  5. ↑ Hellauer K, et al. (2001) Decreased expression of specific genes in yeast cells lacking histone H1. J Biol Chem 276(17):13587-92 SGD PMID 11278859
  6. ↑ Landsman D (1996) Histone H1 in Saccharomyces cerevisiae: a double mystery solved? Trends Biochem Sci 21(8):287-8 SGD PMID 8772381
  7. ↑ Patterton HG, et al. (1998) The biochemical and phenotypic characterization of Hho1p, the putative linker histone H1 of Saccharomyces cerevisiae. J Biol Chem 273(13):7268-76 SGD PMID 9516420
  8. ↑ 8.0 8.1 8.2 Puig S, et al. (1999) Stochastic nucleosome positioning in a yeast chromatin region is not dependent on histone H1. Curr Microbiol 39(3):168-72 SGD PMID 10441732
  9. ↑ Ushinsky SC, et al. (1997) Histone H1 in Saccharomyces cerevisiae. Yeast 13(2):151-61 SGD PMID 9046096
  10. ↑ 10.0 10.1 submitted by Jose E. Perez-Ortin on 2004-05-27

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