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Systematic name YPL127C
Gene name HHO1
Feature type ORF, Verified
Coordinates Chr XVI:309604..308828
Primary SGDID S000006048

Description of YPL127C: Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination[1][2][3][4][5][6][7][8][9]


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Alleles, Strains, and Phenotypes

Complete Deletion

Strain Background: S288c
Genotype: BQS238: MATalfa, ura3-52, leu2-3,112, ade2-101, suc2-delta9, gal2, hho1delta0, pRB58
Phenotype(s): No Phenotype, Deletion of HHO1 has no effect on nucleosome positioning, Viable

Hho1p has no effect on nucleosome positioning in yeast. [8] [10]

DNA and RNA Details

Other DNA and RNA Details

Other Topic: Nucleosome positioning

We analyzed a chromatin region of the yeast Chromosome (Chr) IX, in which there are two closely packed open reading frames (ORFs), POT1 and YIL161w. This locus shows a regular ladder of 13 stochastically positioned nucleosomes, which is unaffected by the absence of the HHO1 gene. This suggests that histone H1 has no effect on nucleosome positioning in yeast. [8] [10]



See Help:References on how to add references

  1. Bryant JM, et al. (2012) The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae. Mol Cell Biol 32(14):2771-83 SGD PMID 22586276
  2. Downs JA, et al. (2003) Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Mol Cell 11(6):1685-92 SGD PMID 12820979
  3. Escher D and Schaffner W (1997) Gene activation at a distance and telomeric silencing are not affected by yeast histone H1. Mol Gen Genet 256(4):456-61 SGD PMID 9393443
  4. Freidkin I and Katcoff DJ (2001) Specific distribution of the Saccharomyces cerevisiae linker histone homolog HHO1p in the chromatin. Nucleic Acids Res 29(19):4043-51 SGD PMID 11574687
  5. Hellauer K, et al. (2001) Decreased expression of specific genes in yeast cells lacking histone H1. J Biol Chem 276(17):13587-92 SGD PMID 11278859
  6. Landsman D (1996) Histone H1 in Saccharomyces cerevisiae: a double mystery solved? Trends Biochem Sci 21(8):287-8 SGD PMID 8772381
  7. Patterton HG, et al. (1998) The biochemical and phenotypic characterization of Hho1p, the putative linker histone H1 of Saccharomyces cerevisiae. J Biol Chem 273(13):7268-76 SGD PMID 9516420
  8. 8.0 8.1 8.2 Puig S, et al. (1999) Stochastic nucleosome positioning in a yeast chromatin region is not dependent on histone H1. Curr Microbiol 39(3):168-72 SGD PMID 10441732
  9. Ushinsky SC, et al. (1997) Histone H1 in Saccharomyces cerevisiae. Yeast 13(2):151-61 SGD PMID 9046096
  10. 10.0 10.1 submitted by Jose E. Perez-Ortin on 2004-05-27

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