YOR351C

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Systematic name YOR351C
Gene name MEK1
Aliases MRE4
Feature type ORF, Verified
Coordinates Chr XV:996508..995015
Primary SGDID S000005878


Description of YOR351C: Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids[1][2][3][4][5]




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References

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  1. Niu H, et al. (2007) Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis. Mol Cell Biol () SGD PMID 17526735
  2. Bailis JM and Roeder GS (2000) Pachytene exit controlled by reversal of Mek1-dependent phosphorylation. Cell 101(2):211-21 SGD PMID 10786836
  3. Rockmill B and Roeder GS (1991) A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Genes Dev 5(12B):2392-404 SGD PMID 1752435
  4. Bailis JM, et al. (2000) Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins. Mol Cell Biol 20(13):4838-48 SGD PMID 10848609
  5. Leem SH and Ogawa H (1992) The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 20(3):449-57 SGD PMID 1741279

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