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Systematic name YOR351C
Gene name MEK1
Aliases MRE4
Feature type ORF, Verified
Coordinates Chr XV:996511..995018
Primary SGDID S000005878

Description of YOR351C: Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids[1][2][3][4][5]


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  1. Bailis JM and Roeder GS (2000) Pachytene exit controlled by reversal of Mek1-dependent phosphorylation. Cell 101(2):211-21 SGD PMID 10786836
  2. Bailis JM, et al. (2000) Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins. Mol Cell Biol 20(13):4838-48 SGD PMID 10848609
  3. Leem SH and Ogawa H (1992) The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 20(3):449-57 SGD PMID 1741279
  4. Niu H, et al. (2007) Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis. Mol Cell Biol 27(15):5456-67 SGD PMID 17526735
  5. Rockmill B and Roeder GS (1991) A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Genes Dev 5(12B):2392-404 SGD PMID 1752435

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