YOR294W

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Systematic name YOR294W
Gene name RRS1
Aliases
Feature type ORF, Verified
Coordinates Chr XV:868339..868950
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Description of YOR294W: Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice[1][2][3][4]



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References

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  1. Fossale E, et al. (2002) Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice. Hum Mol Genet 11(19):2233-41 SGD PMID 12217951
  2. Miyoshi K, et al. (2004) Rrs1p, a ribosomal protein L11-binding protein, is required for nuclear export of the 60S pre-ribosomal subunit in Saccharomyces cerevisiae. FEBS Lett 565(1-3):106-10 SGD PMID 15135061
  3. Morita D, et al. (2002) Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. J Biol Chem 277(32):28780-6 SGD PMID 12048200
  4. Tsuno A, et al. (2000) RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. Mol Cell Biol 20(6):2066-74 SGD PMID 10688653

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