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Systematic name YOR294W
Gene name RRS1
Feature type ORF, Verified
Coordinates Chr XV:868340..868951
Primary SGDID S000005820

Description of YOR294W: Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice[1][2][3][4][5]


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  1. Fossale E, et al. (2002) Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice. Hum Mol Genet 11(19):2233-41 SGD PMID 12217951
  2. Horigome C, et al. (2011) Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.LID - 10.1038/emboj.2011.267 [doi] EMBO J () SGD PMID 21822217
  3. Miyoshi K, et al. (2004) Rrs1p, a ribosomal protein L11-binding protein, is required for nuclear export of the 60S pre-ribosomal subunit in Saccharomyces cerevisiae. FEBS Lett 565(1-3):106-10 SGD PMID 15135061
  4. Morita D, et al. (2002) Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. J Biol Chem 277(32):28780-6 SGD PMID 12048200
  5. Tsuno A, et al. (2000) RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. Mol Cell Biol 20(6):2066-74 SGD PMID 10688653

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