Difference between revisions of "YOR254C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005780 YOR254C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005780 YOR254C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SEC63 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SEC63 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:807024..805033
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|nowrap| Chr XV:807023..805032
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000005780
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000005780

Latest revision as of 07:45, 23 January 2012

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Systematic name YOR254C
Gene name SEC63
Aliases PTL1
Feature type ORF, Verified
Coordinates Chr XV:807023..805032
Primary SGDID S000005780


Description of YOR254C: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER[1][2][3]




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Community Commentary

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Interactions

Two Hybrid

Two Hybrid interaction with SEC62
Amino terminal domain of Sec62p (residues 1-149) interacts with c-terminal 39 residues of Sec63p [2] [4]





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References

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  1. Misselwitz B, et al. (1999) Interaction of BiP with the J-domain of the Sec63p component of the endoplasmic reticulum protein translocation complex. J Biol Chem 274(29):20110-5 SGD PMID 10400622
  2. 2.0 2.1 Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 SGD PMID 12518317
  3. Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 SGD PMID 11226176
  4. submitted by Colin Stirling on 2003-02-05

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