YOR254C
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| Systematic name | YOR254C |
| Gene name | SEC63 |
| Aliases | PTL1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:807023..805032 |
| Primary SGDID | S000005780 |
Description of YOR254C: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER[1][2][3]
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Community Commentary
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Interactions
Two Hybrid
Two Hybrid interaction with SEC62
Amino terminal domain of Sec62p (residues 1-149) interacts with c-terminal 39 residues of Sec63p [2] [4]
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References
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- ↑ Misselwitz B, et al. (1999) Interaction of BiP with the J-domain of the Sec63p component of the endoplasmic reticulum protein translocation complex. J Biol Chem 274(29):20110-5 SGD PMID 10400622
- ↑ 2.0 2.1 Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 SGD PMID 12518317
- ↑ Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 SGD PMID 11226176
- ↑ submitted by Colin Stirling on 2003-02-05
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