Difference between revisions of "YOR197W"
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| − | '''Description of YOR197W:''' | + | '''Description of YOR197W:''' Ca2+-activated cysteine protease; may cleave specific substrates during stress response; involved in regulation of apoptosis upon H2O2 treatment; contributes to clearance of insoluble protein aggregates during normal growth; may be involved in cell cycle progression; similar to mammalian caspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet with the 6 caspase-common beta-strands, blocking potential dimerization<ref name='S000127360'>Lee RE, et al. (2008) A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics. PLoS ONE 3(8):e2956 {{SGDpaper|S000127360}} PMID 18698411</ref><ref name='S000135026'>Lee RE, et al. (2010) Metacaspase Yca1 is required for clearance of insoluble protein aggregates. Proc Natl Acad Sci U S A 107(30):13348-53 {{SGDpaper|S000135026}} PMID 20624963</ref><ref name='S000070033'>Madeo F, et al. (2002) A caspase-related protease regulates apoptosis in yeast. Mol Cell 9(4):911-7 {{SGDpaper|S000070033}} PMID 11983181</ref><ref name='S000150038'>Wong AH, et al. (2012) Crystal structure of the yeast metacaspase Yca1. J Biol Chem () |
| − | {{SGDpaper| | + | {{SGDpaper|S000150038}} PMID 22761449</ref> |
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Latest revision as of 14:05, 19 July 2012
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| Systematic name | YOR197W |
| Gene name | MCA1 |
| Aliases | YCA1, [MCA] |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:717086..718384 |
| Primary SGDID | S000005723 |
Description of YOR197W: Ca2+-activated cysteine protease; may cleave specific substrates during stress response; involved in regulation of apoptosis upon H2O2 treatment; contributes to clearance of insoluble protein aggregates during normal growth; may be involved in cell cycle progression; similar to mammalian caspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet with the 6 caspase-common beta-strands, blocking potential dimerization[1][2][3][4]
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References
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- ↑ Lee RE, et al. (2008) A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics. PLoS ONE 3(8):e2956 SGD PMID 18698411
- ↑ Lee RE, et al. (2010) Metacaspase Yca1 is required for clearance of insoluble protein aggregates. Proc Natl Acad Sci U S A 107(30):13348-53 SGD PMID 20624963
- ↑ Madeo F, et al. (2002) A caspase-related protease regulates apoptosis in yeast. Mol Cell 9(4):911-7 SGD PMID 11983181
- ↑ Wong AH, et al. (2012) Crystal structure of the yeast metacaspase Yca1. J Biol Chem () SGD PMID 22761449
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