Difference between revisions of "YOR164C"

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'''Description of YOR164C:''' Protein of unknown function, highly conserved across species and homologous to human gene C7orf20; interacts with Mdy2p; genetic interactions predict a role in insertion of tail-anchored proteins into the ER membrane<ref name='S000126590'>Fernandes JM, et al. (2008) Genomic, evolutionary, and expression analyses of cee, an ancient gene involved in normal growth and development. Genomics 91(4):315-25 {{SGDpaper|S000126590}} PMID 18249086</ref><ref name='S000115662'>Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 {{SGDpaper|S000115662}} PMID 16702403</ref><ref name='S000129738'>Jonikas MC, et al. (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7
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'''Description of YOR164C:''' Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20<ref name='S000132933'>Chang YW, et al. (2010) Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1. J Biol Chem 285(13):9962-70 {{SGDpaper|S000132933}} PMID 20106980</ref><ref name='S000126590'>Fernandes JM, et al. (2008) Genomic, evolutionary, and expression analyses of cee, an ancient gene involved in normal growth and development. Genomics 91(4):315-25 {{SGDpaper|S000126590}} PMID 18249086</ref><ref name='S000115662'>Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 {{SGDpaper|S000115662}} PMID 16702403</ref><ref name='S000129738'>Jonikas MC, et al. (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7
 
  {{SGDpaper|S000129738}} PMID 19325107</ref>
 
  {{SGDpaper|S000129738}} PMID 19325107</ref>
 
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Revision as of 14:05, 31 August 2010

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Systematic name YOR164C
Gene name GET4
Aliases
Feature type ORF, Verified
Coordinates Chr XV:644333..643395
Primary SGDID S000005690


Description of YOR164C: Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20[1][2][3][4]




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References

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  1. Chang YW, et al. (2010) Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1. J Biol Chem 285(13):9962-70 SGD PMID 20106980
  2. Fernandes JM, et al. (2008) Genomic, evolutionary, and expression analyses of cee, an ancient gene involved in normal growth and development. Genomics 91(4):315-25 SGD PMID 18249086
  3. Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 SGD PMID 16702403
  4. Jonikas MC, et al. (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7 SGD PMID 19325107

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