Difference between revisions of "YNL118C"
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| − | '''Description of YNL118C:''' Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family<ref name=' | + | '''Description of YNL118C:''' Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family<ref name='S000041554'>Gaudon C, et al. (1999) Role of the essential yeast protein PSU1 in p6anscriptional enhancement by the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 18(8):2229-40 {{SGDpaper|S000041554}} PMID 10205176</ref><ref name='S000059255'>Dunckley T, et al. (2001) Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics 157(1):27-37 {{SGDpaper|S000059255}} PMID 11139489</ref><ref name='S000113839'>She M, et al. (2006) Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. Nat Struct Mol Biol 13(1):63-70 |
| − | {{SGDpaper| | + | {{SGDpaper|S000113839}} PMID 16341225</ref> |
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Revision as of 14:05, 31 March 2009
Share your knowledge...Edit this entry! <protect>
| Systematic name | YNL118C |
| Gene name | DCP2 |
| Aliases | PSU1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:405566..402654 |
| Primary SGDID | S000005062 |
Description of YNL118C: Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family[1][2][3]
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Contents
Community Commentary
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DNA and RNA Details
RNA Degradation
Yeast Dcp2 is catalitically active to cleave the cap structure of mRNAs [4] [5]
Interactions
Two Hybrid
Two Hybrid interaction with NAM7
Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins [6] [7]
Protein Details
Nucleic Acid Binding
YNL118C binds RNA Interacts with substrate mRNA to cleave cap structure but not with free cap. [4] [5]
Other Protein Details
Other Topic: Motif
Contains a MUT T/NUDIX motif as well as other specific conserved regions [4] [5]
Techniques and Reagents
Protein Purification
Recombinant protein (truncated) [4] [5]
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References
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- ↑ Gaudon C, et al. (1999) Role of the essential yeast protein PSU1 in p6anscriptional enhancement by the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 18(8):2229-40 SGD PMID 10205176
- ↑ Dunckley T, et al. (2001) Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics 157(1):27-37 SGD PMID 11139489
- ↑ She M, et al. (2006) Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. Nat Struct Mol Biol 13(1):63-70 SGD PMID 16341225
- ↑ 4.0 4.1 4.2 4.3 van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 SGD PMID 12486012
- ↑ 5.0 5.1 5.2 5.3 submitted by Bertrand Seraphin on 2003-09-03
- ↑ He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 SGD PMID 7883168
- ↑ submitted by Jurgen Wittmann on 2003-04-30
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
Categories:
- ORF
- ORF, Verified
- Topic:DNA and RNA Details
- Topic:DNA and RNA Details:RNA Degradation
- Topic:Interactions
- Topic:Interactions:Two Hybrid
- Two Hybrid Interactions with NAM7
- Topic:Protein Details
- Topic:Protein Details:Nucleic Acid Binding
- Binds RNA
- Topic:Protein Details:Other Protein Details
- Topic:Motif
- Topic:Techniques and Reagents
- Topic:Techniques and Reagents:Protein Purification
