Difference between revisions of "YMR080C"

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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Revision as of 13:02, 21 February 2007

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Systematic name YMR080C
Gene name NAM7
Aliases IFS2, MOF4, UPF1
Feature type ORF, Verified
Coordinates Chr XIII:429626..426711


Description of YMR080C: ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance[1][2]




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Interactions

Two Hybrid

Two Hybrid interaction with SNP1, NMD3, DBP2, NMD4, DCP2, NMD5, NMD2
Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins [3] [4]




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References

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  1. Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
  2. de la Cruz J, et al. (1999) Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24(5):192-8 SGD PMID 10322435
  3. He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 SGD PMID 7883168
  4. submitted by Jurgen Wittmann on 2003-04-30

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