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Systematic name YMR080C
Gene name NAM7
Aliases IFS2, MOF4, SUP113, UPF1
Feature type ORF, Verified
Coordinates Chr XIII:429627..426712
Primary SGDID S000004685

Description of YMR080C: ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance[1][2][3][4]


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Two Hybrid

Two Hybrid interaction with SNP1, NMD3, DBP2, NMD4, DCP2, NMD5, NMD2
Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins [5] [6]



See Help:References on how to add references

  1. Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
  2. Sheth U and Parker R (2006) Targeting of aberrant mRNAs to cytoplasmic processing bodies. Cell 125(6):1095-109 SGD PMID 16777600
  3. Takahashi S, et al. (2008) Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA 14(9):1950-8 SGD PMID 18676617
  4. de la Cruz J, et al. (1999) Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24(5):192-8 SGD PMID 10322435
  5. He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 SGD PMID 7883168
  6. submitted by Jurgen Wittmann on 2003-04-30

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