Difference between revisions of "YMR080C"
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| − | '''Description of YMR080C:''' ATP-dependent RNA helicase of the SFI superfamily | + | '''Description of YMR080C:''' ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance<ref name='S000061923'>de la Cruz J, et al. (1999) Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24(5):192-8 {{SGDpaper|S000061923}} PMID 10322435</ref><ref name='S000114270'>Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 {{SGDpaper|S000114270}} PMID 15161972</ref><ref name='S000116680'>Sheth U and Parker R (2006) Targeting of aberrant mRNAs to cytoplasmic processing bodies. Cell 125(6):1095-109 {{SGDpaper|S000116680}} PMID 16777600</ref><ref name='S000127349'>Takahashi S, et al. (2008) Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA 14(9):1950-8 |
{{SGDpaper|S000127349}} PMID 18676617</ref> | {{SGDpaper|S000127349}} PMID 18676617</ref> | ||
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Revision as of 14:05, 1 April 2009
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| Systematic name | YMR080C |
| Gene name | NAM7 |
| Aliases | IFS2, MOF4, UPF1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:429626..426711 |
| Primary SGDID | S000004685 |
Description of YMR080C: ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance[1][2][3][4]
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Community Commentary
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Interactions
Two Hybrid
Two Hybrid interaction with SNP1, NMD3, DBP2, NMD4, DCP2, NMD5, NMD2
Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins [5] [6]
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References
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- ↑ de la Cruz J, et al. (1999) Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24(5):192-8 SGD PMID 10322435
- ↑ Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
- ↑ Sheth U and Parker R (2006) Targeting of aberrant mRNAs to cytoplasmic processing bodies. Cell 125(6):1095-109 SGD PMID 16777600
- ↑ Takahashi S, et al. (2008) Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA 14(9):1950-8 SGD PMID 18676617
- ↑ He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 SGD PMID 7883168
- ↑ submitted by Jurgen Wittmann on 2003-04-30
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