Difference between revisions of "YML034W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YML034W YML034W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004497 YML034W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SRC1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SRC1 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''YML033W''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''HEH1, YML033W''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
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|nowrap| Chr XIII:209525..212155
 
|nowrap| Chr XIII:209525..212155
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000004497
 
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'''Description of {{PAGENAME}}:''' Protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery<ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000069006'>Rodriguez-Navarro S, et al. (2002) SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Yeast 19(1):43-54
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'''Description of YML034W:''' Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance<ref name='S000127665'>Grund SE, et al. (2008) The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression. J Cell Biol 182(5):897-910 {{SGDpaper|S000127665}} PMID 18762579</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000123937'>King MC, et al. (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442(7106):1003-7 {{SGDpaper|S000123937}} PMID 16929305</ref><ref name='S000145470'>Mishra SK, et al. (2011) Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature () {{SGDpaper|S000145470}} PMID 21614000</ref><ref name='S000069006'>Rodriguez-Navarro S, et al. (2002) SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Yeast 19(1):43-54 {{SGDpaper|S000069006}} PMID 11754482</ref><ref name='S000136872'>Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83 {{SGDpaper|S000136872}} PMID 20850176</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
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=== Protein Details ===
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==== Protein Modification ====
 
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'''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]]
 
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Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-29'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-29</ref>
 
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==Community Commentary==
 
==Community Commentary==
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YML034W
Gene name SRC1
Aliases HEH1, YML033W
Feature type ORF, Verified
Coordinates Chr XIII:209525..212155
Primary SGDID S000004497


Description of YML034W: Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance[1][2][3][4][5][6][7]




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Community Commentary

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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [7] [8]




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References

See Help:References on how to add references

  1. ↑ Grund SE, et al. (2008) The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression. J Cell Biol 182(5):897-910 SGD PMID 18762579
  2. ↑ Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
  3. ↑ King MC, et al. (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442(7106):1003-7 SGD PMID 16929305
  4. ↑ Mishra SK, et al. (2011) Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature () SGD PMID 21614000
  5. ↑ Rodriguez-Navarro S, et al. (2002) SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Yeast 19(1):43-54 SGD PMID 11754482
  6. ↑ Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83 SGD PMID 20850176
  7. ↑ 7.0 7.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  8. ↑ submitted by Jeff Ubersax on 2004-01-29

See Help:Categories on how to add the wiki page for this gene to a Category </protect>

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