YML034W
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| Systematic name | YML034W |
| Gene name | SRC1 |
| Aliases | HEH1, YML033W |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:209525..212155 |
| Primary SGDID | S000004497 |
Description of YML034W: Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance[1][2][3][4][5][6][7]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [7] [8]
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References
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- ↑ Grund SE, et al. (2008) The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression. J Cell Biol 182(5):897-910 SGD PMID 18762579
- ↑ Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
- ↑ King MC, et al. (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442(7106):1003-7 SGD PMID 16929305
- ↑ Mishra SK, et al. (2011) Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature () SGD PMID 21614000
- ↑ Rodriguez-Navarro S, et al. (2002) SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Yeast 19(1):43-54 SGD PMID 11754482
- ↑ Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83 SGD PMID 20850176
- ↑ 7.0 7.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ submitted by Jeff Ubersax on 2004-01-29
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