Difference between revisions of "YLR056W"
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| − | '''Description of YLR056W:''' C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources<ref name='S000042704'>Arthington BA, et al. (1991) Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase. Gene 102(1):39-44 {{SGDpaper|S000042704}} PMID 1864507</ref><ref name='S000039457'>Lees ND, et al. (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6 {{SGDpaper|S000039457}} PMID 7791529</ref><ref name='S000058496'>Paltauf F, et al. (1992) Regulation and compartmentalization of lipid synthesis in yeast. Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press {{SGDpaper|S000058496}} PMID </ref><ref name='S000039432'>Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 | + | '''Description of YLR056W:''' C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase<ref name='S000042704'>Arthington BA, et al. (1991) Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase. Gene 102(1):39-44 {{SGDpaper|S000042704}} PMID 1864507</ref><ref name='S000147802'>Jaenicke LA, et al. (2011) Yos9p assists in the degradation of certain nonglycosylated proteins from the endoplasmic reticulum. Mol Biol Cell 22(16):2937-45 {{SGDpaper|S000147802}} PMID 21737688</ref><ref name='S000039457'>Lees ND, et al. (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6 {{SGDpaper|S000039457}} PMID 7791529</ref><ref name='S000058496'>Paltauf F, et al. (1992) Regulation and compartmentalization of lipid synthesis in yeast. Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press {{SGDpaper|S000058496}} PMID </ref><ref name='S000039432'>Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 |
{{SGDpaper|S000039432}} PMID 7791530</ref> | {{SGDpaper|S000039432}} PMID 7791530</ref> | ||
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Latest revision as of 14:05, 24 February 2012
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| Systematic name | YLR056W |
| Gene name | ERG3 |
| Aliases | PSO6, SYR1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:253861..254958 |
| Primary SGDID | S000004046 |
Description of YLR056W: C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase[1][2][3][4][5]
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Community Commentary
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Erg3 is activated by Dap1 (damage resistance protein 1), a heme-binding protein which shares some homology with cytochrome b5. Episterol accumulates in strains mutated for DAP1. Dap1p also activates Erg11, but dap1 strains engineered to over-express ERG11 have remarkable levels of episterol and other sterol intermediates. The mechanism through which Dap1p activates Erg3p is not known.
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References
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- ↑ Arthington BA, et al. (1991) Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase. Gene 102(1):39-44 SGD PMID 1864507
- ↑ Jaenicke LA, et al. (2011) Yos9p assists in the degradation of certain nonglycosylated proteins from the endoplasmic reticulum. Mol Biol Cell 22(16):2937-45 SGD PMID 21737688
- ↑ Lees ND, et al. (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6 SGD PMID 7791529
- ↑ Paltauf F, et al. (1992) Regulation and compartmentalization of lipid synthesis in yeast. Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press SGD PMID
- ↑ Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 SGD PMID 7791530
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References
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See Help:Categories on how to add the wiki page for this gene to a Category </protect>
