YLR056W

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Systematic name YLR056W
Gene name ERG3
Aliases PSO6, SYR1
Feature type ORF, Verified
Coordinates Chr XII:253861..254958
Primary SGDID S000004046


Description of YLR056W: C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase[1][2][3][4][5]




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Community Commentary

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Erg3 is activated by Dap1 (damage resistance protein 1), a heme-binding protein which shares some homology with cytochrome b5. Episterol accumulates in strains mutated for DAP1. Dap1p also activates Erg11, but dap1 strains engineered to over-express ERG11 have remarkable levels of episterol and other sterol intermediates. The mechanism through which Dap1p activates Erg3p is not known.




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References

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  1. Arthington BA, et al. (1991) Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase. Gene 102(1):39-44 SGD PMID 1864507
  2. Jaenicke LA, et al. (2011) Yos9p assists in the degradation of certain nonglycosylated proteins from the endoplasmic reticulum. Mol Biol Cell 22(16):2937-45 SGD PMID 21737688
  3. Lees ND, et al. (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6 SGD PMID 7791529
  4. Paltauf F, et al. (1992) Regulation and compartmentalization of lipid synthesis in yeast. Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press SGD PMID
  5. Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 SGD PMID 7791530

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References

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