Difference between revisions of "YKL184W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001667 YKL184W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SPE1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SPE1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XI: | + | |nowrap| Chr XI:96757..98157 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001667 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001667 | ||
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| − | '''Description of YKL184W:''' Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines<ref name='S000065211'>Fonzi WA (1989) Biochemical and genetic characterization of the structure of yeast ornithine decarboxylase. Biochem Biophys Res Commun 162(3):1409-16 {{SGDpaper|S000065211}} PMID 2669750</ref><ref name='S000056998'>Fonzi WA and Sypherd PS (1987) The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae. J Biol Chem 262(21):10127-33 {{SGDpaper|S000056998}} PMID 3038869</ref><ref name='S000056394'>Toth C and Coffino P (1999) Regulated degradation of yeast ornithine decarboxylase. J Biol Chem 274(36):25921-6 | + | '''Description of YKL184W:''' Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation<ref name='S000131896'>Eisenberg T, et al. (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11(11):1305-14 {{SGDpaper|S000131896}} PMID 19801973</ref><ref name='S000065211'>Fonzi WA (1989) Biochemical and genetic characterization of the structure of yeast ornithine decarboxylase. Biochem Biophys Res Commun 162(3):1409-16 {{SGDpaper|S000065211}} PMID 2669750</ref><ref name='S000056998'>Fonzi WA and Sypherd PS (1987) The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae. J Biol Chem 262(21):10127-33 {{SGDpaper|S000056998}} PMID 3038869</ref><ref name='S000056394'>Toth C and Coffino P (1999) Regulated degradation of yeast ornithine decarboxylase. J Biol Chem 274(36):25921-6 |
{{SGDpaper|S000056394}} PMID 10464336</ref> | {{SGDpaper|S000056394}} PMID 10464336</ref> | ||
<br> | <br> | ||
Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YKL184W |
| Gene name | SPE1 |
| Aliases | ORD1, SPE10 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:96757..98157 |
| Primary SGDID | S000001667 |
Description of YKL184W: Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation[1][2][3][4]
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References
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- ↑ Eisenberg T, et al. (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11(11):1305-14 SGD PMID 19801973
- ↑ Fonzi WA (1989) Biochemical and genetic characterization of the structure of yeast ornithine decarboxylase. Biochem Biophys Res Commun 162(3):1409-16 SGD PMID 2669750
- ↑ Fonzi WA and Sypherd PS (1987) The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae. J Biol Chem 262(21):10127-33 SGD PMID 3038869
- ↑ Toth C and Coffino P (1999) Regulated degradation of yeast ornithine decarboxylase. J Biol Chem 274(36):25921-6 SGD PMID 10464336
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