From SGD-Wiki
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YKL184W
Gene name SPE1
Aliases ORD1, SPE10
Feature type ORF, Verified
Coordinates Chr XI:96757..98157
Primary SGDID S000001667

Description of YKL184W: Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation[1][2][3][4]


Community Commentary

About Community Commentary. Please share your knowledge!



See Help:References on how to add references

  1. Eisenberg T, et al. (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11(11):1305-14 SGD PMID 19801973
  2. Fonzi WA (1989) Biochemical and genetic characterization of the structure of yeast ornithine decarboxylase. Biochem Biophys Res Commun 162(3):1409-16 SGD PMID 2669750
  3. Fonzi WA and Sypherd PS (1987) The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae. J Biol Chem 262(21):10127-33 SGD PMID 3038869
  4. Toth C and Coffino P (1999) Regulated degradation of yeast ornithine decarboxylase. J Biol Chem 274(36):25921-6 SGD PMID 10464336

See Help:Categories on how to add the wiki page for this gene to a Category </protect>