Difference between revisions of "YKL139W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001622 YKL139W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CTK1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CTK1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XI: | + | |nowrap| Chr XI:182958..184544 |
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001622 |
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| − | '''Description of | + | '''Description of YKL139W:''' Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13<ref name='S000138559'>Bartkowiak B, et al. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev 24(20):2303-16 {{SGDpaper|S000138559}} PMID 20952539</ref><ref name='S000055627'>Lee JM and Greenleaf AL (1991) CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae. Gene Expr 1(2):149-67 {{SGDpaper|S000055627}} PMID 1820212</ref><ref name='S000123934'>Rother S and Strasser K (2007) The RNA polymerase II CTD kinase Ctk1 functions in translation elongation. Genes Dev 21(11):1409-21 {{SGDpaper|S000123934}} PMID 17545469</ref><ref name='S000071951'>Skaar DA and Greenleaf AL (2002) The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Mol Cell 10(6):1429-39 |
| − | {{SGDpaper| | + | {{SGDpaper|S000071951}} PMID 12504017</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YKL139W |
| Gene name | CTK1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:182958..184544 |
| Primary SGDID | S000001622 |
Description of YKL139W: Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13[1][2][3][4]
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Contents
Community Commentary
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References
See Help:References on how to add references
- ↑ Bartkowiak B, et al. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev 24(20):2303-16 SGD PMID 20952539
- ↑ Lee JM and Greenleaf AL (1991) CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae. Gene Expr 1(2):149-67 SGD PMID 1820212
- ↑ Rother S and Strasser K (2007) The RNA polymerase II CTD kinase Ctk1 functions in translation elongation. Genes Dev 21(11):1409-21 SGD PMID 17545469
- ↑ Skaar DA and Greenleaf AL (2002) The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Mol Cell 10(6):1429-39 SGD PMID 12504017
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