YKL139W

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Systematic name YKL139W
Gene name CTK1
Aliases
Feature type ORF, Verified
Coordinates Chr XI:182958..184544
Primary SGDID S000001622


Description of YKL139W: Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13[1][2][3][4]




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References

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  1. Bartkowiak B, et al. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev 24(20):2303-16 SGD PMID 20952539
  2. Lee JM and Greenleaf AL (1991) CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae. Gene Expr 1(2):149-67 SGD PMID 1820212
  3. Rother S and Strasser K (2007) The RNA polymerase II CTD kinase Ctk1 functions in translation elongation. Genes Dev 21(11):1409-21 SGD PMID 17545469
  4. Skaar DA and Greenleaf AL (2002) The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Mol Cell 10(6):1429-39 SGD PMID 12504017

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