Difference between revisions of "YKL032C"
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 13:02, 21 February 2007
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| Systematic name | YKL032C |
| Gene name | IXR1 |
| Aliases | ORD1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:381501..379708 |
Description of YKL032C: Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b[1][2][3]
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References
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- ↑ Chow CS, et al. (1994) HMG domain proteins induce sharp bends in cisplatin-modified DNA. Biochemistry 33(50):15124-30 SGD PMID 7999772
- ↑ Lambert JR, et al. (1994) The ORD1 gene encodes a transcription factor involved in oxygen regulation and is identical to IXR1, a gene that confers cisplatin sensitivity to Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 91(15):7345-9 SGD PMID 8041793
- ↑ Brown SJ, et al. (1993) Ixr1, a yeast protein that binds to platinated DNA and confers sensitivity to cisplatin. Science 261(5121):603-5 SGD PMID 8342024
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