YKL032C
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| Systematic name | YKL032C |
| Gene name | IXR1 |
| Aliases | ORD1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:381858..380065 |
| Primary SGDID | S000001515 |
Description of YKL032C: Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b[1][2][3]
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References
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- ↑ Brown SJ, et al. (1993) Ixr1, a yeast protein that binds to platinated DNA and confers sensitivity to cisplatin. Science 261(5121):603-5 SGD PMID 8342024
- ↑ Chow CS, et al. (1994) HMG domain proteins induce sharp bends in cisplatin-modified DNA. Biochemistry 33(50):15124-30 SGD PMID 7999772
- ↑ Lambert JR, et al. (1994) The ORD1 gene encodes a transcription factor involved in oxygen regulation and is identical to IXR1, a gene that confers cisplatin sensitivity to Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 91(15):7345-9 SGD PMID 8041793
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