Difference between revisions of "YJR050W"
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| − | '''Description of YJR050W:''' | + | '''Description of YJR050W:''' Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles<ref name='S000046470'>Chen CH, et al. (2001) Identification and characterization of two novel components of the Prp19p-associated complex, Ntc30p and Ntc20p. J Biol Chem 276(1):488-94 {{SGDpaper|S000046470}} PMID 11018040</ref><ref name='S000115006'>Chen CH, et al. (2006) Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling. RNA 12(5):765-74 {{SGDpaper|S000115006}} PMID 16540691</ref><ref name='S000069405'>Chen CH, et al. (2002) Functional and physical interactions between components of the Prp19p-associated complex. Nucleic Acids Res 30(4):1029-37 {{SGDpaper|S000069405}} PMID 11842115</ref><ref name='S000071476'>Dahan O and Kupiec M (2002) Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint. Nucleic Acids Res 30(20):4361-70 |
{{SGDpaper|S000071476}} PMID 12384582</ref> | {{SGDpaper|S000071476}} PMID 12384582</ref> | ||
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Revision as of 14:05, 22 October 2009
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| Systematic name | YJR050W |
| Gene name | ISY1 |
| Aliases | NTC30, UTR3 |
| Feature type | ORF, Verified |
| Coordinates | Chr X:528689..529396 |
| Primary SGDID | S000003811 |
Description of YJR050W: Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles[1][2][3][4]
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References
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- ↑ Chen CH, et al. (2001) Identification and characterization of two novel components of the Prp19p-associated complex, Ntc30p and Ntc20p. J Biol Chem 276(1):488-94 SGD PMID 11018040
- ↑ Chen CH, et al. (2006) Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling. RNA 12(5):765-74 SGD PMID 16540691
- ↑ Chen CH, et al. (2002) Functional and physical interactions between components of the Prp19p-associated complex. Nucleic Acids Res 30(4):1029-37 SGD PMID 11842115
- ↑ Dahan O and Kupiec M (2002) Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint. Nucleic Acids Res 30(20):4361-70 SGD PMID 12384582
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