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Systematic name YJR050W
Gene name ISY1
Aliases NTC30, UTR3
Feature type ORF, Verified
Coordinates Chr X:528697..529404
Primary SGDID S000003811

Description of YJR050W: Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles[1][2][3][4]


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  1. Chen CH, et al. (2001) Identification and characterization of two novel components of the Prp19p-associated complex, Ntc30p and Ntc20p. J Biol Chem 276(1):488-94 SGD PMID 11018040
  2. Chen CH, et al. (2002) Functional and physical interactions between components of the Prp19p-associated complex. Nucleic Acids Res 30(4):1029-37 SGD PMID 11842115
  3. Chen CH, et al. (2006) Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling. RNA 12(5):765-74 SGD PMID 16540691
  4. Dahan O and Kupiec M (2002) Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint. Nucleic Acids Res 30(20):4361-70 SGD PMID 12384582

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