YJL210W

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Systematic name YJL210W
Gene name PEX2
Aliases CRT1, PAS5
Feature type ORF, Verified
Coordinates Chr X:36919..37734
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Description of YJL210W: RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms putative translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import[1][2]



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Protein Details

Other Protein Details

Other Topic: Homology

Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [3] [4]


References

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  1. Hazra PP, et al. (2002) Peroxisome remnants in pex3delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Traffic 3(8):560-74 SGD PMID 12121419
  2. Gould SJ and Valle D (2000) Peroxisome biogenesis disorders: genetics and cell biology. Trends Genet 16(8):340-5 SGD PMID 10904262
  3. Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
  4. submitted by Toni Gabaldon on 2006-04-12

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