From SGD-Wiki
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YJL210W
Gene name PEX2
Aliases CRT1, PAS5
Feature type ORF, Verified
Coordinates Chr X:36919..37734
Primary SGDID S000003746

Description of YJL210W: RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import[1][2][3]


Community Commentary

About Community Commentary. Please share your knowledge!

Protein Details

Other Protein Details

Other Topic: Homology

Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [4] [5]



See Help:References on how to add references

  1. Gould SJ and Valle D (2000) Peroxisome biogenesis disorders: genetics and cell biology. Trends Genet 16(8):340-5 SGD PMID 10904262
  2. Hazra PP, et al. (2002) Peroxisome remnants in pex3delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Traffic 3(8):560-74 SGD PMID 12121419
  3. Platta HW, et al. (2009) Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import. Mol Cell Biol 29(20):5505-16 SGD PMID 19687296
  4. Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
  5. submitted by Toni Gabaldon on 2006-04-12

See Help:Categories on how to add the wiki page for this gene to a Category </protect>