Difference between revisions of "YJL187C"

From SGD-Wiki
Jump to: navigation, search
(Automated import of articles)
(Automated import of articles)
Line 4: Line 4:
 
{|{{Prettytable}} align = 'right' width = '200px'
 
{|{{Prettytable}} align = 'right' width = '200px'
 
|-
 
|-
−
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YJL187C YJL187C]  
+
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003723 YJL187C]  
 
|-
 
|-
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SWE1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SWE1 ''
Line 14: Line 14:
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|nowrap| Chr X:79261..76802
 
|nowrap| Chr X:79261..76802
 +
|-
 +
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003723
 
|}
 
|}
 
<br>
 
<br>
−
'''Description of {{PAGENAME}}:''' Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate<ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000043338'>Longtine MS, et al. (2000) Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20(11):4049-61 {{SGDpaper|S000043338}} PMID 10805747</ref><ref name='S000042140'>Booher RN, et al. (1993) Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J 12(9):3417-26
+
'''Description of YJL187C:''' Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate<ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000043338'>Longtine MS, et al. (2000) Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20(11):4049-61 {{SGDpaper|S000043338}} PMID 10805747</ref><ref name='S000042140'>Booher RN, et al. (1993) Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J 12(9):3417-26
 
  {{SGDpaper|S000042140}} PMID 8253069</ref>
 
  {{SGDpaper|S000042140}} PMID 8253069</ref>
 
<br>
 
<br>
Line 83: Line 85:
 
J Biol Chem 278(5):3265-74</ref>
 
J Biol Chem 278(5):3265-74</ref>
 
-->
 
-->
 +
 +
  
 
<protect>
 
<protect>

Revision as of 08:46, 27 February 2007

Share your knowledge...Edit this entry! <protect>

Systematic name YJL187C
Gene name SWE1
Aliases WEE1
Feature type ORF, Verified
Coordinates Chr X:79261..76802
Primary SGDID S000003723


Description of YJL187C: Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate[1][2][3]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!

Alleles, Strains, and Phenotypes

Complete Deletion

Strain Background: W303
Genotype: SH24: swe1::URA3 bar1
Phenotype(s): Loss of function (Null), Premature entry into mitosis, Viable

Despite previous reports to the contrary, swe1 mutant cells enter mitosis prematurely at a reduced bud size. [4] [5]

Point Mutation

Strain Background: BF264-15D
Phenotype(s): Dominant, stabilized

Deletion or mutation of residues between Leu320 and Tyr332 stabilizes Swe1p. [6] [7]

Interactions

Other Interactions

Other Topic: NOT Regulatory Other Interactions interaction with MET30
Despite previous reports to the contrary, Met30p is not required for Swe1p degradation [6] [7]

Other

Localization

Swe1p localization to the neck abolished by mutations in residues Leu320, Leu324, Phe327, Lys328,Leu331, or Tyr332 [6] [7]

Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [1] [8]




<protect>

References

See Help:References on how to add references

  1. ↑ 1.0 1.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  2. ↑ Longtine MS, et al. (2000) Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20(11):4049-61 SGD PMID 10805747
  3. ↑ Booher RN, et al. (1993) Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J 12(9):3417-26 SGD PMID 8253069
  4. ↑ Harvey SL and Kellogg DR (2003) Conservation of mechanisms controlling entry into mitosis: budding yeast wee1 delays entry into mitosis and is required for cell size control. Curr Biol 13(4):264-75 SGD PMID 12593792
  5. ↑ submitted by Stacy Harvey on 2005-06-08
  6. ↑ 6.0 6.1 6.2 McMillan JN, et al. (2002) Determinants of Swe1p degradation in Saccharomyces cerevisiae. Mol Biol Cell 13(10):3560-75 SGD PMID 12388757
  7. ↑ 7.0 7.1 7.2 submitted by Daniel Lew on 2003-03-03
  8. ↑ submitted by Jeff Ubersax on 2004-01-27

See Help:Categories on how to add the wiki page for this gene to a Category </protect>

Retrieved from "https://wiki.yeastgenome.org/index.php?title=YJL187C&oldid=46669"