Difference between revisions of "YIR010W"
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr IX:375428..377158 | |nowrap| Chr IX:375428..377158 | ||
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==Community Commentary== | ==Community Commentary== | ||
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Revision as of 08:17, 30 January 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YIR010W |
| Gene name | DSN1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:375428..377158 |
Description of YIR010W: Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation[1][2]
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Community Commentary
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Interactions
Genetic
YIR010W is a suppressor of MTW1
Strain Background: W303
DSN1 is a high copy suppressor of the mtw1-1 mutant. [3] [4]
Physical
Physical interaction with NSL1
Nsl1p co-immunoprecipitates Dsn1p. [3] [4]
Physical interaction with NNF1
Nnf1p co-immunoprecipitates Dsn1p. [3] [4]
Physical interaction with MTW1
Mtw1p co-immunoprecipitates Dsn1p. [3] [4]
Physical interaction with CSE4
Cse4p co-immunopreciptates with Dsn1p. [3] [4]
Physical interaction with MIF2
Mif2p co-immunoprecipitates Dsn1p. [3] [4]
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References
See Help:References on how to add references
- ↑ De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21 SGD PMID 14633972
- ↑ Euskirchen GM (2002) Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell 1(2):229-40 SGD PMID 12455957
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 submitted by Benjamin Pinsky on 2004-03-04
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