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Systematic name YIR010W
Gene name DSN1
Feature type ORF, Verified
Coordinates Chr IX:375431..377161
Primary SGDID S000001449

Description of YIR010W: Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation[1][2]


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YIR010W is a suppressor of MTW1

Strain Background: W303 (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)

DSN1 is a high copy suppressor of the mtw1-1 mutant. [3] [4]


Physical interaction with NSL1
Nsl1p co-immunoprecipitates Dsn1p. [3] [4]

Physical interaction with NNF1
Nnf1p co-immunoprecipitates Dsn1p. [3] [4]

Physical interaction with MTW1
Mtw1p co-immunoprecipitates Dsn1p. [3] [4]

Physical interaction with CSE4
Cse4p co-immunopreciptates with Dsn1p. [3] [4]

Physical interaction with MIF2
Mif2p co-immunoprecipitates Dsn1p. [3] [4]



See Help:References on how to add references

  1. De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21 SGD PMID 14633972
  2. Euskirchen GM (2002) Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell 1(2):229-40 SGD PMID 12455957
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
  4. 4.0 4.1 4.2 4.3 4.4 4.5 submitted by Benjamin Pinsky on 2004-03-04

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