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| − | === Interactions ===
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| − | [[Category:Topic:Interactions]]
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| − | ==== Genetic ====
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| − | [[Category:Topic:Interactions:Genetic]]
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| − | YIR010W is a suppressor of MTW1 [[Category:Genetic Interaction with MTW1]]
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| − | '''Strain Background''': W303<br>
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| − | DSN1 is a high copy suppressor of the mtw1-1 mutant. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − | {{ShortCenteredHR}}
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| − | ==== Physical ====
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| − | [[Category:Topic:Interactions:Physical]]
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| − | Physical interaction with NSL1 [[Category:Physical Interactions with NSL1]]<br>
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| − | Nsl1p co-immunoprecipitates Dsn1p. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − | {{ShortCenteredHR}}
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| − | Physical interaction with NNF1 [[Category:Physical Interactions with NNF1]]<br>
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| − | Nnf1p co-immunoprecipitates Dsn1p. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | Physical interaction with MTW1 [[Category:Physical Interactions with MTW1]]<br>
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| − | Mtw1p co-immunoprecipitates Dsn1p. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − | {{ShortCenteredHR}}
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| − | Physical interaction with CSE4 [[Category:Physical Interactions with CSE4]]<br>
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| − | Cse4p co-immunopreciptates with Dsn1p. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − | {{ShortCenteredHR}}
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| − | Physical interaction with MIF2 [[Category:Physical Interactions with MIF2]]<br>
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| − | Mif2p co-immunoprecipitates Dsn1p. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − | {{ShortCenteredHR}}
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| | __TOC__ | | __TOC__ |
| | ==Community Commentary== | | ==Community Commentary== |
Revision as of 11:51, 24 January 2007
Share your knowledge...Edit this entry!
| Systematic name |
YIR010W
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| Gene name |
DSN1
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| Aliases |
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| Feature type |
ORF, Verified
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| Coordinates
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Chr IX:375428..377158
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| Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs.
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Description of YIR010W: Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation[1][2]
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Interactions
Genetic
YIR010W is a suppressor of MTW1
Strain Background: W303
DSN1 is a high copy suppressor of the mtw1-1 mutant. [3] [4]
Physical
Physical interaction with NSL1
Nsl1p co-immunoprecipitates Dsn1p. [3] [4]
Physical interaction with NNF1
Nnf1p co-immunoprecipitates Dsn1p. [3] [4]
Physical interaction with MTW1
Mtw1p co-immunoprecipitates Dsn1p. [3] [4]
Physical interaction with CSE4
Cse4p co-immunopreciptates with Dsn1p. [3] [4]
Physical interaction with MIF2
Mif2p co-immunoprecipitates Dsn1p. [3] [4]
References
See Help:References on how to add references
- ↑ De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21 SGD PMID 14633972
- ↑ Euskirchen GM (2002) Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell 1(2):229-40
SGD PMID 12455957
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 submitted by Benjamin Pinsky on 2004-03-04
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