YIL022W

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Systematic name YIL022W
Gene name TIM44
Aliases ISP45, MIM44, MPI1
Feature type ORF, Verified
Coordinates Chr IX:311163..312458
Primary SGDID S000001284


Description of YIL022W: Peripheral mitochondrial membrane protein involved in mitochondrial protein import, tethers essential chaperone Ssc1p to the translocon channel at the matrix side of the inner membrane[1][2][3]




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References

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  1. D'Silva P, et al. (2004) Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane. Nat Struct Mol Biol 11(11):1084-91 SGD PMID 15489862
  2. Voos W, et al. (1996) Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins. EMBO J 15(11):2668-77 SGD PMID 8654364
  3. Geissler A, et al. (2000) Biogenesis of the yeast frataxin homolog Yfh1p. Tim44-dependent transfer to mtHsp70 facilitates folding of newly imported proteins in mitochondria. Eur J Biochem 267(11):3167-80 SGD PMID 10824101

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