Difference between revisions of "YHR216W"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:17, 30 January 2007

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Systematic name YHR216W
Gene name IMD2
Aliases PUR5
Feature type ORF, Verified
Coordinates Chr VIII:554396..555967


Description of YHR216W: Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation[1][2]




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Community Commentary

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References

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  1. Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90 SGD PMID 12917348
  2. Hyle JW, et al. (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8 SGD PMID 12746440

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