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Systematic name YHR216W
Gene name IMD2
Aliases PUR5
Feature type ORF, Verified
Coordinates Chr VIII:554396..555967
Primary SGDID S000001259

Description of YHR216W: Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio[1][2][3][4]


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  1. Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 SGD PMID 11035032
  2. Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90 SGD PMID 12917348
  3. Hyle JW, et al. (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8 SGD PMID 12746440
  4. Shaw RJ, et al. (2001) Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast. J Biol Chem 276(35):32905-16 SGD PMID 11441018

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